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That means that the number of sequential steps along the way – what chemists make reference to as the longest linear sequence – ought to be as small as possible to maximize production. For example, if a sequence offers 30 steps and each step has an 80 % yield, the entire yield of the sequence is about one-tenth of a %. At the same time, one low-yield stage will knock an activity out of contention. The longest linear sequence in the Serratezomine A synthesis is definitely 15 methods and it comes with an overall yield of 1 1.7 %, Johnston says. That’s an average yield of 77 % per step. The sequence was kept by The chemists this short by using a strategy called convergence.